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Psychedelic Definition, Meaning & Synonyms The mGlu5 negative allosteric modulator MPEP (30 mg/kg) also significantly increased locomotor activity in WT mice, measured as distance traveled, during the first 50 minutes of the 1-hour test session, but had no effect on activity in mGlu5 KO animals. DOM (0.5. mg/kg) increased locomotor activity in WT mice, but only during the third 10-minute block of testing, whereas DOM significantly and markedly increased locomotor activity in all six 10-minute blocks of testing in mGlu5 KO mice. Locomotor hyperactivity in mGlu5 KO mice was significantly attenuated by 1.0 mg/kg M100907, and M completely blocked the hyperactivity induced by MPEP. One possible explanation offered by Halberstadt et al. is that the loss of mGlu5 signaling may lead to increased 5-HT release, which activates the 5-HT2A receptor (see Stachowicz et al., 2007). The DOM potentiation of activity in mGlu5 KO mice could also be attributed to enhanced sensitivity of 5HT2A recept